IgG4-Related Disease as Mimicker of Malignancy

Abstract Background IgG4-related disease (IgG4-RD) is an immune-mediated that may present as a tumefactive lesion in nearly any organ. These mass lesions often resemble malignancy both clinically and radiologically, some patients undergo surgical resection which could possibly be avoided with early recognition of IgG4-RD. We performed retrospective single-center study examining how many IgG4-RD were initially believed to have malignancy, particular attention those who underwent potentially avoidable procedures. Methods Sixty-three biopsy confirmed included. Clinical, laboratory, radiological, histological data collected analyzed. Results Over 60% (38/63) thought when they presented symptomatic The most common types suspected lymphoma (18/38) pancreatic cancer (11/38). Of the 38 14 invasive intervention either alleviate severity their symptoms or treatment for presumed malignancy. included Whipple resection/attempted (3), nephrectomy bile duct reconstruction (1), removal other abdominal/retroperitoneal masses stenting obstructed organs (4). Conclusion should on differential diagnosis lesions, obstructive jaundice, extensive lymphadenopathy, retroperitoneal masses. Oncologists physicians involved care aware various manifestations diagnostic approach order provide accurate minimize unnecessary While procedures this study, such organs, required regardless diagnosis, others been attenuated Patients suspicious serum protein electrophoresis, IgG subclass measurement, and, where possible, tissue before undergoing major resection. Consultation physician experienced recommended.